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Disulfiram (generic Antabuse) produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Antabuse blocks the oxidation of alcohol at the acetaldehyde stage. During alcohol metabolism after Antabuse intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone.
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